Lois Angela Mead is the daughter of Stephen Mead of Bedford, Middlesex County, Massachusetts, and Adeline Russ of Brunswick County, North Carolina. She married Henry Weston on 15 Jul 1858 in Gainsville, Hancock County, Mississippi.

They had the following children:
Adaline “Addie” Eliza Weston born 01 Oct 1859 married D.H. Snow
Asa Sidney Weston born 22 Jul 1861 married Marion Edith Otis
Horatio Stephen Weston born 26 Aug 1863 married Elizabeth A. Wall
Coney Daniel Weston born 05 Jun 1866 married Annie Kennedy
Carrie Weston born 14 Mar 1868; died 22 Mar 1869
John Henry Weston born 23 Feb 1870 married Sarah Amelia Baxter
David Robert Weston born 13 May 1872 married Pauline May Gosselin
Abner Coburn Weston born 27 Aug 1874 married Heloise Penny
Lois Angela Weston born 19 May 1876 married Roland Taylor Patten